TRANSFORMING BONE REPAIR
RevBio Animal Health was started with one goal in mind—to end veterinary medicine’s 50 year search for a biocompatible bone adhesive. Effective for bone-to-bone as well as bone-to-metal wet field applications, Tetranite Vet ® is a revolutionary biomaterial that promises to transform bone repair—for both patients and clinicians.
TETRANITE®VET IS TRANSFORMING BONE REPAIR
Inspired by the marine animal the sandcastle worm, Tetranite Vet is elegant chemistry. Bioengineered from the worm’s secreted protein, our synthetic adhesive bone graft is the only patented biomaterial which satisfies both the required and desired properties for a bone adhesive: wet field performance, multi-surface bonding, rapid mechanical stability and controlled biodegradability.
TETRANITE® IS INNOVATIVE TECHNOLOGY
A SIMPLE MECHANISM OF ACTION
READ OUR SELECT PUBLICATIONS
TETRANITE TECHNOLOGY
Tetranite contains mineral-organic compounds modeled on natural materials. Once mixed with an aqueous medium, the material undergoes a transformation from a pliable putty to a cement-like adhesive scaffold. Once on the market, Tetranite will become the first synthetic bone adhesive. As a synthetic product, Tetranite does not rely on large molecules and therefore can be produced in large quantities at a low cost.
MECHANISM OF ACTION
The components in Tetranite react within minutes to yield a uniquely adhesive composite system. After hardening, Tetranite is bioengineered to withstand tensile and shear bond stresses as high as 3 MPa, similar to the strength of human cancellous bone. The Tetranite scaffold is osteoconductive and bioactive, leading to the eventual replacement of Tetranite with new bone. Over time, load bearing responsibility is transferred to the new tissue such that mechanical integrity is maintained.
SELECT PUBLICATIONS
The body of evidence for the efficacy of Tetranite for bonding bone-to-bone as well as bone-to-metal is growing. Read some of our latest published studies and press releases.
- Biomechanical Testing of a Calcium Phosphate-Phosphoserine–Based Mineral-Organic Adhesive for Non-invasive Fracture Repair of Mandibular Fractures in Dogs: Alexander T. Geddes, Graham P. Thatcher, Scott Hetzel, Ronald P. McCabe, Ray Vandereby Jr. and Christopher J. Snyder
- Bone Glue—The Final Frontier for Fracture Stabilization and Implantable Device Stabilization: M.R. Norton, G. Kay, M. Brown, D.L. Cochran.
- Bioinspired Mineral–Organic Bioresorbable Bone Adhesive: Alina Kirillova, Cambre Kelly, Natalia von Windheim, and Ken Gall.
FROM THE BENCH TO THE TABLE
LOWELL, Mass., Feb. 04, 2021 /PRNewswire/ — RevBio, Inc. RevBio Enters the Animal Health Market to Help Improve Canine Dental Care.
RevBio Animal Health is conducting a study evaluating the rate of bone healing using a novel adhesive bone graft in tooth extraction sites in dogs. For information, visit our Clinical Trials Page.
THE TETRANITE® VET PIPELINE
As Tetranite Vet’s technology is the foundation of a comprehensive platform, RevBio Animal Health has developed a roadmap for bringing our solutions to market across multiple applications and indications.
